The microchromatographic estimation of fetal hemoglobin levels in hereditary persistence of fetal hemoglobin.
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چکیده
5. Warren RJ, Moss DW. An automated continuous-monitoring procedure for the determination of acid phosphatase activity in serum. Clin Chim Acta 77, 179-188 (1977). 6. Gundlach G, Muhlhausen B. Untersuchungen zur Kupplung des 1-Naphthols mit Fast-red-TR. J Clin Chem Clin Biochem 18, 603-610 (1980). 7. Babson AL, Read PA. A new assay for prostatic acid phosphatase in serum. Am J Clin Pathol 32, 88-91 (1959). 8. Sudhof H, Neumann G, Oloffs J. aNaphthylphosphate as a substrate for measuring acid phosphatase of prostatic origin. German Med Monthly 9, 15-20 (1964). 9. Seal US, Mellinger GT, Doe RP. A study of phenyl phosphate and a-naphthyl phosphate as substrates for serum acid phosphatase. Ciin Chem 12, 620-631 (1966). 10 Babson AL, Phillips GE. An improved acid phosphatase procedure. Clin Chim Acta 13, 264-265 (1966). 11. Bruhn HD, Keller H. A comparison of methods for the estimation of”prostatic acid phosphatase.” German Med Monthly 12, 109-112 (1967). 12. Babson AL, Read PA, Phillips GE. The importance of the substrate in assays of acid phosphatase in serum. Am J Clin Pathol 32, 83-87 (1959). 13. Roy AV, Brewer ME, Hayden JE. Sodium thymolphthalein monophosphate: A new acid phosphatase substrate with greater specificity for the prostatic enzyme in serum. Clin Chem 17, 1093-1102 (1971). 14. van Run HJM, Boer P, Kiosse JA. The determination of acid phosphatase of prostatic origin with the automatic clinical arialyzer (ace, DuPont). J Clin Chem Clin Binchem 18, 627-630 (1980). 15. Babson AL. A new endogenous immunoenzyme assay for pro8tatic acid phosphatase evaluated. Clin Chem 30, (1984). In press.
منابع مشابه
Nature of fetal hemoglobin in the Greek type of hereditary persistence of fetal hemoglobin with and without concurrent beta-thalassemia.
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عنوان ژورنال:
- Clinical chemistry
دوره 30 8 شماره
صفحات -
تاریخ انتشار 1984